Glycogen Storage Disease Type 1

I received a call this morning from the nurse at the OB's office that my prenatal tests came back positive for Glycogen Storage Disease Type 1. If Jimmy tests positive, then we'll have to go to genetic counseling. So, we went to the lab and Jimmy had the blood test done. Now we wait and see what his test results come back as.

Glycogen storage disease type I (GSD I) or von Gierke's disease, is the most common of the glycogen storage diseases. This genetic disease results from deficiency of the enzyme glucose-6-phosphatase. This deficiency impairs the ability of the liver to produce free glucose from glycogen and from gluconeogenesis. Since these are the two principal metabolic mechanisms by which the liver supplies glucose to the rest of the body during periods of fasting, it causes severe hypoglycemia. Reduced glycogen breakdown results in increased glycogen storage in liver and kidneys, causing enlargement of both. Both organs function normally in childhood but are susceptible to a variety of problems in the adult years. Other metabolic derangements include lactic acidosis and hyperlipidemia. Frequent or continuous feedings of cornstarch or othercarbohydrates are the principal treatment. Other therapeutic measures may be needed for associated problems.